Increased prostacyclin and thromboxane production in man during cardiopulmonary bypass

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

Mats Hámberg, Jan Olof Svensson, B Samuelsson · Proceedings of the National Academy of Sciences · 1975 · 3.1K citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +14

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

Salvador Moncada, John R. Vane · New England Journal of Medicine · 1979 · 1.2K citations

Life Sciences, Biochemistry, Pharmacology +17

The chemical structure of prostaglandin X (prostacyclin)

Roy A. Johnson, Douglas R. Morton, John H. Kinner et al. · Prostaglandins · 1976 · 730 citations

Natural Sciences, Chemistry, Pharmacology +10

Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets

J.E. Tateson, Salvador Moncada, John R. Vane · Prostaglandins · 1977 · 603 citations

Medicine, Biochemistry, Pharmacology +14