Concepedia

Pd catalyzed facile synthesis of cyclopenta[b]quinolin-1-one via sequential Sonogashira coupling and annulation. An unusual mode of ring closure, using sulphur as a soft nucleophile

Radhey M. Singh, Ritush Kumar, Kishor Chandra Bharadwaj, Tanu Gupta

Organic Chemistry Frontiers · 2016 · 28 citations · 56 references

DOI

Concepts

Abstract

Pd mediated one pot sequential Sonogashira coupling followed by annulation using <italic>o</italic>-alkynyl aldehyde is reported.

References

56

Copper(II)‐Catalyzed Three‐Component Cascade Annulation of Diaryliodoniums, Nitriles, and Alkynes: A Regioselective Synthesis of Multiply Substituted Quinolines

Yong Wang, Chao Chen, Jing Peng et al. · Angewandte Chemie International Edition · 2013 · 238 citations

, , +15

Direct Mannich and Nitro‐Mannich Reactions with Non‐Activated Imines: AgOTf‐Catalyzed Addition of Pronucleophiles to <i>ortho</i>‐Alkynylaryl Aldimines Leading to 1,2‐Dihydroisoquinolines

Naoki Asao, Salprima Yudha S., Tsutomu Nogami et al. · Angewandte Chemie International Edition · 2005 · 219 citations

, , +8

Carbocycle Synthesis via Carbopalladation of Nitriles

Richard C. Larock, Qingping Tian, Alexandre A. Pletnev · Journal of the American Chemical Society · 1999 · 216 citations

, , +4

Concise Synthesis of 1,2-Dihydroisoquinolines and 1<i>H</i>-Isochromenes by Carbophilic Lewis Acid-Catalyzed Tandem Nucleophilic Addition and Cyclization of 2-(1-Alkynyl)arylaldimines and 2-(1-Alkynyl)arylaldehydes

Shingo Obika, Hideki Kono, Yoshizumi Yasui et al. · The Journal of Organic Chemistry · 2007 · 207 citations

, , +17

Sonogashira coupling in natural product synthesis

Dan Wang, Shuanhu Gao · Organic Chemistry Frontiers · 2014 · 207 citations

, , +12