Concise Synthesis of 1,2-Dihydroisoquinolines and 1<i>H</i>-Isochromenes by Carbophilic Lewis Acid-Catalyzed Tandem Nucleophilic Addition and Cyclization of 2-(1-Alkynyl)arylaldimines and 2-(1-Alkynyl)arylaldehydes

Shingo Obika, Hideki Kono, Yoshizumi Yasui, +2

The Journal of Organic Chemistry

Concise SynthesisCross-coupling Reaction1H-isochromene DerivativesEngineeringBiochemistry +11

In(OTf)₃‐Catalyzed Tandem Nucleophilic Addition and Cyclization of <i>ortho</i>‐Alkynylarylaldimines to 1,2‐Dihydroisoquinolines

Reiko Yanada, Shingo Obika, Hideki Kono, +1

Angewandte Chemie International Edition

Tandem Nucleophilic AdditionCross-coupling ReactionEngineeringBiochemistryNatural Sciences +11

Stereoselective Synthesis of 3-Alkylideneoxindoles via Palladium-Catalyzed Domino Reactions

Reiko Yanada, Shingo Obika, Tsubasa Inokuma, +4

The Journal of Organic Chemistry

Stereoselective Synthesis of 3-Alkylideneoxindoles Using Tandem In-Mediated Carbometalation and Pd-Catalyzed Cross-Coupling Reaction

Reiko Yanada, Shingo Obika, Munetaka Oyama, +1

Organic Letters

Asymmetric CatalysisCross-coupling ReactionEngineeringTandem In-mediated CarbometalationOrganic Chemistry +7

Indium-Mediated Atom-Transfer and Reductive Radical Cyclizations of Iodoalkynes:  Synthesis and Biological Evaluation of HIV-Protease Inhibitors

Reiko Yanada, Yasuhiro Koh, Nobuaki Nishimori, +5

The Journal of Organic Chemistry

Combinatorial ChemistryOrganic ChemistryChemistryHeterocycle ChemistryMedicinal Chemistry +15

SAR Exploration Guided by LE and Fsp ³ : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, +29

ACS Medicinal Chemistry Letters

Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling

Ken Katsuya, Daisuke Oikawa, Kiyosei Iio, +5

Biochemical and Biophysical Research Communications

Protein FunctionSignaling PathwayNatural SciencesMolecular BiologySmall-molecule Inhibitors +7

Stereoselective Synthesis of 3‐Alkylideneoxindoles using Tandem Indium‐Mediated Carbometallation and Palladium‐Catalyzed Cross‐Coupling Reactions

Reiko Yanada, Shingo Obika, Yusuke Kobayashi, +4

Advanced Synthesis & Catalysis

Cross-coupling ReactionEngineeringNatural SciencesTmc‐95a PrecursorDiversity-oriented Synthesis +10

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders

Satoru Noji, Yoshinori Hara, Tomoya Miura, +17

Journal of Medicinal Chemistry

Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses

Daisuke Oikawa, Yusuke Sato, Fumiaki Ohtake, +16

Communications Biology