In(OTf)₃‐Catalyzed Tandem Nucleophilic Addition and Cyclization of <i>ortho</i>‐Alkynylarylaldimines to 1,2‐Dihydroisoquinolines

Abstract

Multitasking catalyst: 1,2-Dihydroisoquinoline derivatives are prepared in good yields by an In(OTf)3-catalyzed tandem annulation reaction. The catalyst activates both the imine and alkyne to the addition of various nucleophiles and the subsequent intramolecular cyclization (see picture; OTf=trifluoromethanesulfonate). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600408_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.