<i>Ogg1</i> -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis

Abstract

OGG1 plays a protective role in atherogenesis by preventing excessive inflammasome activation. Our study provides insight into a new target for therapeutic intervention based on a link between oxidative mtDNA damage, OGG1, and atherosclerosis via NLRP3 inflammasome.