Thymosin alpha 1 suppresses proliferation and induces apoptosis in breast cancer cells through PTEN-mediated inhibition of PI3K/Akt/mTOR signaling pathway

Cancer statistics, 2013

Rebecca L. Siegel, Deepa Naishadham, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2013 · 11.9K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.6K citations · Full text

Life Sciences, Cell Biology, Oncology +16

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

Yoichi Nagata, Keng‐Hsueh Lan, Xiaoyan Zhou et al. · Cancer Cell · 2004 · 1.9K citations · Full text

Medicine, Cancer Biology, Oncology +14

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

Scott Kennedy, Andrew J. Wagner, Suzanne D. Conzen et al. · Genes & Development · 1997 · 1.1K citations · Full text

Life Sciences, Cell Biology, Apoptosis +16

Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair

Lao H. Saal, Sofia K. Gruvberger-Saal, C. Persson et al. · Nature Genetics · 2007 · 351 citations · Full text

Life Sciences, Genetics, Oncology +15