Concepedia

Visualizing Differences in Ligand Regulation of Wild-Type and Constitutively Active Mutant β<sub>2</sub>-Adrenoceptor-Green Fluorescent Protein Fusion Proteins

Alison J. McLean, Nicola Bevan, Stephen Edward Rees, Graeme Milligan

Molecular Pharmacology · 1999 · 35 citations · 21 references

DOI

Concepts

References

21

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

Philippe Samama, Susanna Cotecchia, Tommaso Costa et al. · Journal of Biological Chemistry · 1993 · 1.3K citations · Full text

, , +17

Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor

Ulrik Gether · The EMBO Journal · 1997 · 388 citations · Full text

, , +16

Structural Instability of a Constitutively Active G Protein-coupled Receptor

Ulrik Gether, Roland Seifert, Juan Antonio Ballesteros‐Cánovas et al. · Journal of Biological Chemistry · 1997 · 299 citations · Full text

, , +17

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

Graeme Milligan, Richard A. Bond, Melanie Lee · Trends in Pharmacological Sciences · 1995 · 294 citations

, , +13

Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

Philippe Samama, Gang Pei, Tommaso Costa et al. · Molecular Pharmacology · 1994 · 238 citations

, , +17