Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.6K citations · Full text

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher et al. · Neurosignals · 2012 · 3.4K citations · Full text

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe et al. · Nature · 2004 · 1.6K citations · Full text

Obesity, Metabolic Syndrome, Nutrition +11

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Ffolliott M. Fisher, Sandra Kleiner, Nicholas Douris et al. · Genes & Development · 2012 · 1.4K citations · Full text

Human Growth, Metabolic Remodeling, Cellular Physiology +20

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen et al. · Developmental Cell · 2006 · 1.4K citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +8