Adipocyte-specific deletion of mTOR inhibits adipose tissue development and causes insulin resistance in mice

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Pontus Boström, Jun Wu, Mark P. Jedrychowski et al. · Nature · 2012 · 4.7K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher et al. · Neurosignals · 2012 · 3.4K citations · Full text

Life Sciences, Endocrinology, Physiology +17

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Sung Hee Um, Francesca Frigerio, Mitsuhiro Watanabe et al. · Nature · 2004 · 1.7K citations · Full text

Medicine, Biochemistry, Endocrinology +14

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Ffolliott M. Fisher, Sandra Kleiner, Nicholas Douris et al. · Genes & Development · 2012 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Physiology +17

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

David A. Guertin, Deanna M. Stevens, Carson C. Thoreen et al. · Developmental Cell · 2006 · 1.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10