Concepedia

COSTIMULATION PATHWAYS IN HOST IMMUNE RESPONSES TO ALLOGENEIC HEPATOCYTES1,2

Ginny L. Bumgardner, Jiashun Li, Marie Heininger, Charles G. Orosz

Transplantation · 1998 · 33 citations · 14 references

Abstract

Host treatment with MR1, but not CTLA4Ig, prolonged hepatocellular allograft survival. These data suggest that CD28/B7 interactions appear relatively unimportant, whereas CD40/CD40L interactions provide critical costimulator signals for T-cell-dependent immune responses to allogeneic hepatocytes.

References

14

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

Stephen P. Schoenberger, René E. M. Toes, Ellen I. H. van der Voort et al. · Nature · 1998 · 2.6K citations

Cd40–cd40l Interactions, T-cell Help, T-regulatory Cell +9

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

J P Ridge, Francesca Di Rosa, Polly Matzinger · Nature · 1998 · 2.3K citations

Dendritic Cell, Temporal Bridge, Immunology +9

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

Sally R.M. Bennett, Freda Karamalis, Richard A. Flavell et al. · Nature · 1998 · 2.1K citations

Adaptive Immune System, Cytotoxic-t-cell Responses, T-regulatory Cell +8

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

Christian P. Larsen, Eric T. Elwood, Diane Z. Alexander et al. · Nature · 1996 · 1.5K citations

Cell Therapy, Transplantation, Composite Allograft +12

Long-Term Survival of Xenogeneic Pancreatic Islet Grafts Induced by CTLA4lg

Deborah J. Lenschow, Yijun Zeng, J. Richard Thistlethwaite et al. · Science · 1992 · 1.1K citations