Concepedia

Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties

Olaf Kinzel, Christoph Steeneck, Thomas Schlüter, Andreas Schulz, Christian Gege, Ulrike K. Hahn, Eva Hambruch, Martin Hornberger, Adriana Spalwisz, Katharina Frick,

Bioorganic & Medicinal Chemistry Letters · 2016 · 31 citations · 20 references

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References

20

Identification of a Nuclear Receptor for Bile Acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa et al. · Science · 1999 · 2.7K citations

, , +17

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Derek J. Parks, Steven G. Blanchard, Randy K. Bledsoe et al. · Science · 1999 · 2.2K citations

, , +17

ICM—A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation

Ruben Abagyan, Maxim Totrov, Dmitry Kuznetsov · Journal of Computational Chemistry · 1994 · 1.7K citations

, , +16

Identification of a nuclear receptor that is activated by farnesol metabolites

Barry M. Forman, Elizabeth C. Goode, Jasmine Chen et al. · Cell · 1995 · 1.2K citations · Full text

, , +14

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

Sunder Mudaliar, Robert R. Henry, Arun J. Sanyal et al. · Gastroenterology · 2013 · 915 citations

, , +12