Christian Gege

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models

Vijaykumar M. Baragi, Gabriele Becher, Alison M. Bendele et al. · Arthritis & Rheumatism · 2009 · 171 citations

Synthesis and biological evaluation of α-ketoamides as inhibitors of the Dengue virus protease with antiviral activity in cell-culture

Christian Steuer, Christian Gege, Wolfgang Fischl et al. · Bioorganic & Medicinal Chemistry · 2011 · 136 citations

Biochemistry, Dengue Virus Protease, Antiviral Activity +8

Closing the Gap: Identification of Human 3-Ketosteroid Reductase, the Last Unknown Enzyme of Mammalian Cholesterol Biosynthesis

Zrinka Marijanovic, Daniela Laubner, Gabriele Möller et al. · Molecular Endocrinology · 2003 · 129 citations

Mammalian Cholesterol Biosynthesis, Molecular Biology, Postsqualene Cholesterol Biosynthesis +17

Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S ₁ ′ Subsite of Matrix Metalloproteinase 8 (MMP-8)

G. Pochetti, Roberta Montanari, Christian Gege et al. · Journal of Medicinal Chemistry · 2009 · 82 citations · Full text

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis

Christian Gege, Bagna Bao, Harald Bluhm et al. · Journal of Medicinal Chemistry · 2011 · 67 citations · Full text

Oral Therapies, Immunology, Non-operative Management +17