The NLRP3 inflammasome and stroke.

TLDR

Inflammasome pattern‑recognition receptors, especially the NLRP3 inflammasome, play key roles in innate immunity and are implicated in atherosclerosis, myocardial infarction, ischemia‑reperfusion injury, and stroke. The review aims to examine how regulating the NLRP3 inflammasome could prevent or treat stroke and identify potential therapeutic targets. It discusses the regulatory pathways of NLRP3 activation that contribute to stroke pathogenesis.

Abstract

Inflammasome pattern recognition receptors, which belong to the family of multi-meric proteins, play an important role in innate immunity, including NLRPs, NLRC, and NAIP. Among these receptors, NLRP3 (nucleotide-binding domain (NOD)-like receptor protein 3) inflammasome may activate the inflammation and participate in atherosclerosis, pathophysiology of myocardial infarction, resultin ischemia/reperfusion injury and stroke and other cardiovascular diseases. Effective regulation of NLRP3 may help prevent or even treat stroke. In recent years, the role of inflammation in stroke has attracted much attention, and the in-depth study of its mechanism of action is gradually clear. This mini-review focuses on the association of regulatory mechanisms of NLRP3 inflammasome with the development of stroke, which may supply some clues for future therapies and novel drug targets for stroke.