Adaptive evolution of complex innovations through stepwise metabolic niche expansion

Exaptation—a Missing Term in the Science of Form

Stephen Jay Gould, Elisabeth S. Vrba · Paleobiology · 1982 · 5K citations

Fitness, Genetics, Natural Selection +17

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

Damian Szklarczyk, Andrea Franceschini, Michael Kuhn et al. · Nucleic Acids Research · 2010 · 3.5K citations · Full text

Genetics, Molecular Biology, Bioinformatics Database +19

Complete set of ORF clones of Escherichia coli ASKA library (A Complete Set of E. coli K-12 ORF Archive): Unique Resources for Biological Research

Masanari Kitagawa, Takeshi Ara, Md Arifuzzaman et al. · DNA Research · 2006 · 1.4K citations · Full text

A genome‐scale metabolic reconstruction for <i>Escherichia coli</i> K‐12 MG1655 that accounts for 1260 ORFs and thermodynamic information

Adam M. Feist, Christopher S. Henry, Jennifer L. Reed et al. · Molecular Systems Biology · 2007 · 1.4K citations · Full text

Metabolic Network, Thermodynamic Information, Molecular Biology +6

High-throughput generation, optimization and analysis of genome-scale metabolic models

Christopher S. Henry, Matthew DeJongh, Aaron A. Best et al. · Nature Biotechnology · 2010 · 1.1K citations

Metabolic Network, Engineering, Computational Biology +7