Partially hydrolyzed guar gum enhances colonic epithelial wound healing via activation of RhoA and ERK1/2

Abstract

In this study, we demonstrate that PHGG promotes colonic epithelial cell wound healing via activation of RhoA, which occurs downstream of ERK1/2 activation. These findings indicate that PHGG could be utilized as a therapeutic agent for patients with intestinal mucosal damage such as those with IBD.