Allosteric Activation Mechanism of the α1β2γ2 γ-Aminobutyric Acid Type A Receptor Revealed by Mutation of the Conserved M2 Leucine

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

On the nature of allosteric transitions: A plausible model

Jacques Monod, Jeffries Wyman, Jean‐Pierre Changeux · Journal of Molecular Biology · 1965 · 8.9K citations

Life Sciences, Biochemistry, Molecular Biology +10

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

Peter R. Schofield, Mark G. Darlison, Norihisa Fujita et al. · Nature · 1987 · 1.6K citations

Life Sciences, Neurobiology, Neuroscience +16

Importance of a novel GABAA receptor subunit for benzodiazepine pharmacology

Dolan B. Pritchett, Harald Sontheimer, Brenda D. Shivers et al. · Nature · 1989 · 1.3K citations

Medicine, Neuroscience, Pharmacology +12

Acetylcholine receptor channel imaged in the open state

Nigel Unwin · Nature · 1995 · 1K citations

Life Sciences, Biophysics, Neuroscience +14