Overestimation of N‐glycoPEGylated factor IX activity in a one‐stage factor IX clotting assay owing to silica‐mediated premature conversion to activated factor IX

Prolonged activity of factor IX as a monomeric Fc fusion protein

Robert Peters, Susan C. Low, George D. Kamphaus et al. · Blood · 2010 · 193 citations

Life Sciences, Biochemistry, Molecular Biology +11

Enhanced pharmacokinetic properties of a glycoPEGylated recombinant factor IX: a first human dose trial in patients with hemophilia B

Claude Négrier, Karin Knobe, Andreas Tiede et al. · Blood · 2011 · 179 citations · Full text

Medicine, Hematology, Pharmacokinetics +13

Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients

Elena Santagostino, Claude Négrier, Robert Klamroth et al. · Blood · 2012 · 172 citations · Full text

Medicine, Hematology, Pharmacokinetics +16

Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients

Amy D. Shapiro, Margaret V. Ragni, Leonard A. Valentino et al. · Blood · 2011 · 170 citations · Full text

Medicine, Hematology, Immunology +17

Genetic fusion to albumin improves the pharmacokinetic properties of factor IX

Thomas Weimer, Ulrich Kronthaler, W Lang et al. · Thrombosis and Haemostasis · 2009 · 156 citations

Medicine, Hematology, Molecular Biology +17