Dimethyl fumarate activates the prostaglandin EP2 receptor and stimulates cAMP signaling in human peripheral blood mononuclear cells

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Ralf A. Linker, De-Hyung Lee, Sarah Ryan et al. · Brain · 2011 · 1.2K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

Robert H. Scannevin, Sowmya Chollate, Mi-Young Jung et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 453 citations

Life Sciences, Neurobiology, Neuroscience +17

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

Henrik Wilms, Jobst Sievers, Uta Rickert et al. · Journal of Neuroinflammation · 2010 · 348 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE

Hui Chen, Julian C. Assmann, Antje Krenz et al. · Journal of Clinical Investigation · 2014 · 298 citations · Full text

Medicine, Immunology, Pharmacology +15

Effects of dimethyl fumarate on neuroprotection and immunomodulation

Philipp Albrecht, Imane Bouchachia, Norbert Goebels et al. · Journal of Neuroinflammation · 2012 · 224 citations · Full text

Life Sciences, Neurology, Neuroscience +17