Sowmya Chollate

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Jeff Sevigny, Ping Chiao, Thierry Bussière et al. · Nature · 2016 · 3K citations

Neurodegenerative Diseases, Alzheimer's Disease, Medicine +7

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

Ralf A. Linker, De-Hyung Lee, Sarah Ryan et al. · Brain · 2011 · 1.1K citations · Full text

Lipid Peroxidation, Immunology, Cell Death +21

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

Robert H. Scannevin, Sowmya Chollate, Mi-Young Jung et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 449 citations

Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator

Hairuo Peng, Tina Talreja, Zhili Xin et al. · ACS Medicinal Chemistry Letters · 2011 · 27 citations · Full text

Protein Secretion, Compound 10A, Pharmacotherapy +20

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach

Zhili Xin, Hairuo Peng, Andrew Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 20 citations · Full text

Biosynthesis, Bioorganic Chemistry, Scaffold Design Approach +10