Concepedia

Second Messengers

Second Messenger is an intracellular signaling molecule that transmits and amplifies extracellular signals by relaying them from receptors on the cell surface to target molecules within the cell, thereby initiating specific cellular responses.

1.1K

Publications

89.4K

Citations

5K

Authors

1.1K

Institutions

Publications per year

2017–2026

105

Variants

Second Messenger

Parents

Children

Publications

1.1K

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Michael J. Berridge, Robin F. Irvine · Nature · 1984 · 6.1K citations

, , +16

cPLA2 is phosphorylated and activated by MAP kinase

Lih‐Ling Lin, Markus Wartmann, Alice Lin et al. · Cell · 1993 · 1.9K citations

, , +8

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes‐Alnemri, Je‐Wook Yu, Pinaki Datta et al. · Nature · 2009 · 1.8K citations · Full text

, , +12

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text

, , +12

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Sharon E Haynes, Gunther Hollopeter, Guang Yang et al. · Nature Neuroscience · 2006 · 1.6K citations

, , +13

1–5 of 1.1K

Authors

5K

  1. HB
    Heinz Breer

    University of Hohenheim, Germany

    11 publications · 1.3K citations

    11

    h-index

  2. IB
    Ingrid Boekhoff

    University of Hohenheim, Germany

    10 publications · 1.2K citations

    10

    h-index

  3. KA
    Kenneth A. Jacobson

    National Institutes of Health, United States

    8 publications · 542 citations

    8

    h-index

  4. RA
    Robert A. Nicholas

    University of North Carolina at Chapel Hill, United States

    7 publications · 661 citations

    7

    h-index

  5. MJ
    Michael J. Berridge

    University of Cambridge, United Kingdom

    6 publications · 7K citations

    6

    h-index

1–5 of 5K

Institutions

1.1K

  1. National Institutes of Health

    Bethesda, United States

    25 h-index

    106 publications

    14K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    64 publications

    6K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    41 publications

    14.8K citations

  4. Inserm

    Paris, France

    15 h-index

    60 publications

    4.6K citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    15 h-index

    68 publications

    8.8K citations

  6. University of California, San Francisco

    San Francisco, United States

    15 h-index

    58 publications

    11.3K citations

  7. Harvard University

    Cambridge, United States

    15 h-index

    59 publications

    12.2K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    14 h-index

    28 publications

    8.3K citations

1–8 of 1.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 52 publications · 6.4K citations

    38

    h-index

  2. Biochemical and Biophysical Research Communications

    BBRC · 62 publications · 2.5K citations

    30

    h-index

  3. PubMed

    Repository · 42 publications · 1.7K citations

    26

    h-index

  4. Nature

    26 publications · 16.2K citations

    24

    h-index

  5. Neuroscience

    19 publications · 1.5K citations

    17

    h-index

1–5