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Metformin attenuates graft-versus-host disease via restricting mammalian target of rapamycin/signal transducer and activator of transcription 3 and promoting adenosine monophosphate–activated protein kinase-autophagy for the balance between T helper 17 and Tregs

InflammationCell AutophagyRapamycin/signal TransducerSignal TransductionSignaling PathwayImmune DysregulationT-regulatory CellAutophagyImmune RegulationImmunologyCell TransplantationTranscription 3Protein Kinase-autophagyMetabolic SignalingMedicineCell BiologyCell SignalingRegulatory T Cell Biology