The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman · Science · 1993 · 7.4K citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Peter Arner, J F, Richard L. Atkinson et al. · Journal of Clinical Investigation · 1995 · 3.5K citations · Full text

Adipose Tissue Expression, Metabolic Disorder, Human Obesity +19

A central role for JNK in obesity and insulin resistance

Jiro Hirosumi, Gürol Tuncman, Lufen Chang et al. · Nature · 2002 · 3.3K citations

Insulin Resistance, Metabolic Syndrome, Obesity +10

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

Roy A. Black, Charles T. Rauch, Carl J. Kozlosky et al. · Nature · 1997 · 3.1K citations

Inflammation, Medicine, Metalloprotein +6

IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

Gökhan S. Hotamışlıgil, Pascal Peraldi, Adriane I. Budavari et al. · Science · 1996 · 2.6K citations