Comparative study of the p53-mdm2 and p53-MDMX interfaces

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

Tumor Biology, Medicine, Rapid Degradation +6

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

Tumor Biology, Tumor Suppressor, Medicine +3

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Oncogenic Agent, Medicine, Molecular Biology +9

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

Sheau-Yann Shieh, Masako Ikeda, Yoichi Taya et al. · Cell · 1997 · 2.1K citations · Full text

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

Roberta Montes de Oca Luna, Daniel S. Wagner, Guillermina Lozano · Nature · 1995 · 1.4K citations

Knockout Mouse, Genome Instability, Developmental Biology +8