Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz, +1

Nature

Tumor BiologyMedicineRapid DegradationProtein DegradationTumor Suppressor +4

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden

Nature

Tumor BiologyTumor SuppressorMedicineCell BiologyCancer Research +1

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson, +2

Cell

Oncogenic AgentMedicineMolecular BiologyP53 ProteinP53-mediated Transactivation +7

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

Sheau-Yann Shieh, Masako Ikeda, Yoichi Taya, +1

Cell

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

Roberta Montes de Oca Luna, Daniel S. Wagner, Guillermina Lozano

Nature

Knockout MouseGenome InstabilityDevelopmental BiologyCell DeathEarly Embryonic Lethality +6

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

Stephen N. Jones, Amy E. Roe, Lawrence A. Donehower, +1

Nature

Knockout MouseGenome InstabilityDevelopmental BiologyEmbryonic LethalityMedicine +6

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

Tanya Gottlieb, Stephen P. Jackson

Cell

ChromatinCell RegulationNatural SciencesDna ReplicationMolecular Biology +8

Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains

Hennie R. Hoogenboom, Andrew D. Griffiths, Kevin S. Johnson, +3

Nucleic Acids Research

Protein AssemblyCoat ProteinBacteriophageMolecular BiologyMinor Coat Protein +18

Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line.

S. Fakharzadeh, Stephen P. Trusko, Donna L. George

The EMBO Journal

Tumor BiologyMedicineCancer Cell BiologyEnhanced ExpressionTumor Suppressor +7

Mapping of the p53 and mdm-2 interaction domains.

Jiandong Chen, Vincent Maréchal, Arnold J. Levine

Molecular and Cellular Biology

P53 FunctionImmunogeneticsInteractomicsMdm-2 Interaction DomainsMedicine +11