Practical Assessment Methodology for Converting Fine Chemicals Processes from Batch to Continuous

Abstract

A practical methodology is proposed to assess the feasibility of converting a batch process into a continuous one. Simple guidelines are illustrated to facilitate decision making at different stages of the evaluation, in particular the swift first decision either to proceed with or kill the idea at the early evaluation stage to avoid wasted effort. The ordered approach also provides a whole process assessment and decision making for the appropriate choice of continuous or hybrid processing mode. Three multistep processes that have been operated at kilogram scale are presented to demonstrate the application of this methodology.