Chemical Engineering & Technology · 2005 · 567 citations · 8 references
EngineeringChemical EngineeringMicrofabricationPharmaceutical ManufacturingReaction EngineeringFine Chemical ManufacturingMicrofabrication ProcessesProcess Scale-upReaction Process DesignFine Chemical SynthesisMicroreactor DesignMicroreactor TechnologyMicroreactorsScale-up Operation
Abstract 50 % of reactions in the fine chemical/pharmaceutical industry could benefit from a continuous process based mainly on microreactor technology. However, the frequent presence of a solid phase still hinders the widespread application of such a technology as a multi‐purpose solution. For small scale and pilot productions, speed in process R&D, as well as the avoidance of scale‐up issues, are the main drivers. On the other hand, for large scale productions, a gain in yield and safety are the main motivations for the use of micoreactor technology. The gain in yield must be significant in order to cope with the increase in capital expenditure associated with the development of a new technology.
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The application of micro reactors to synthetic chemistry
Stephen J. Haswell, Robert Middleton, Brian O’Sullivan et al. · Chemical Communications · 2001 · 220 citations