Drug Discovery Targeted to the Alzheimer's APP mRNA 5'-Untranslated Region: The Action of Paroxetine and Dimercaptopropanol

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

Robert A. Cherny, Craig Atwood, Michel Xilinas et al. · Neuron · 2001 · 1.5K citations · Full text

Life Sciences, Neuroscience, Pharmacology +13

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Christopher Janus, Jacqueline Pearson, JoAnne McLaurin et al. · Nature · 2000 · 1.4K citations

Life Sciences, Neurobiology, Neuroscience +14

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Sascha Weggen, Jason L. Eriksen, Pritam Das et al. · Nature · 2001 · 1.4K citations

Life Sciences, Neuroscience, Pharmacology +14

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

M. Azhar Chishti, Dun-Shen Yang, Christopher Janus et al. · Journal of Biological Chemistry · 2001 · 954 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

Giselle P. Lim, Fu Yang, Tinyi Chu et al. · Journal of Neuroscience · 2000 · 880 citations · Full text

Medicine, Neuroscience, Pharmacology +17