Concepedia

Versatile Approaches for the Synthesis of Fused-Ring γ-Lactones Utilizing Cyclopropane Intermediates

Timothy R. Newhouse, Philip S. J. Kaib, Andrew W. Gross, E. J. Corey

Organic Letters · 2013 · 39 citations · 16 references

DOI

Concepts

Abstract

A highly effective acid-catalyzed cyclopropyl ester to γ-lactone skeletal rearrangement has been demonstrated and applied to the synthesis of a variety of bi- and tricyclic functionalized lactones, rigid and highly compact structures for use as biological probes.

References

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