Hyperuricemia, Oxidative Stress, and Carotid Artery Tone in Experimental Renal Insufficiency

Abstract

Oxonic acid-induced hyperuricemia reduced oxidative stress in vivo, as evaluated using urinary 8-iso-PGF(2 alpha) excretion, increased plasma TRAP, and improved NO-mediated vasorelaxation in the carotid artery in experimental renal insufficiency.