Dissolution Technologies · 2013 · 27 citations · 7 references
PharmacyPharmaceuticsPharmacologyBioavailabilityDissolution TestingPharmaceutical FormulationBiorelevant Dissolution TestingDissolution MediaDrug DissolutionDrug SolubilityFormulation Effects On DissolutionOral BioavailabilityBiorelevant SolubilityDissolution Media PreparationEquilibrium SolubilityFasted-state Dissolution MediaHuman Intestinal FluidSolubilitySolubility - Dissolution RelationshipSolubility Determination
The equilibrium solubility values and dissolution profiles in each of the media (FaSSIF or FaSSIF-V2) produced using methylene chloride and the corresponding SIF Powder are equivalent for the drugs tested representing acid, basic, and neutral compounds. Therefore, it is practical to switch from the more labor-intensive solvent-evaporation method to the use of standardized instant powders for preparing biorelevant media without affecting the solubility and dissolution results.
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Dissolution Media Simulating Fasted and Fed States
Margareth Marques · Dissolution Technologies · 2004 · 114 citations · Full text