The IL-1β/AP-1/miR-30a/ADAMTS-5 axis regulates cartilage matrix degradation in human osteoarthritis

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.3K citations

Dentistry, Genetics, Molecular Genetics +14

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

Shigeru Miyaki, Tempei Sato, Atsushi Inoue et al. · Genes & Development · 2010 · 671 citations · Full text

Medicine, Molecular Genetics, Aging +16

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

Jan Bondeson, S.D. Wainwright, Sarah N. Lauder et al. · Arthritis Research & Therapy · 2006 · 516 citations · Full text

Medicine, Immunology, Orthopaedic Surgery +17

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro

Brigitte Bau, Pia Margarethe Gebhard, Jochen Haag et al. · Arthritis & Rheumatism · 2002 · 384 citations

Dentistry, Molecular Biology, Orthopaedic Surgery +17

Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes

Abdelhamid Liacini · Experimental Cell Research · 2003 · 310 citations

Life Sciences, Cell Biology, Molecular Biology +12