The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

Jan Bondeson, S.D. Wainwright, Sarah N. Lauder, +2

Arthritis Research & Therapy

Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent

Brian M. J. Foxwell, Kylie A. Browne, Jan Bondeson, +4

Proceedings of the National Academy of Sciences

Effective antigen presentation by dendritic cells is NF-κB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines

S. Yoshimura, Jan Bondeson, Brian M. J. Foxwell, +2

International Immunology

Adaptive Immune SystemImmune RegulationImmunologyImmunoeditingImmunologic Mechanism +18

Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

Jan Bondeson, Brian M. J. Foxwell, Fionula M. Brennan, +1

Proceedings of the National Academy of Sciences

The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.

Jan Bondeson, Sami Wainwright, Clare Hughes, +1

PubMed

PathologyAdamts5 AggrecanasesOrthopaedic SurgeryInflammatory ArthritisMusculoskeletal Research +17

Selective regulation of cytokine induction by adenoviral gene transfer of IkappaBalpha into human macrophages: lipopolysaccharide-induced, but not zymosan-induced, proinflammatory cytokines are inhibited, but IL-10 is nuclear factor-kappaB independent.

Jan Bondeson, Kenneth A. Browne, Fionula M. Brennan, +2

PubMed

Immune RegulationImmunologySelective RegulationInnate ImmunityInflammation +20

Selective Regulation of Cytokine Induction by Adenoviral Gene Transfer of IκBα into Human Macrophages: Lipopolysaccharide-Induced, But Not Zymosan-Induced, Proinflammatory Cytokines Are Inhibited, But IL-10 Is Nuclear Factor-κB Independent

Jan Bondeson, Kylie A. Browne, Fionula M. Brennan, +2

The Journal of Immunology

Immune RegulationImmunologyImmunologic MechanismSelective RegulationInnate Immunity +23

Role of NFκB in antigen presentation and development of regulatory T cells elucidated by treatment of dendritic cells with the proteasome inhibitor PSI

S. Yoshimura, Jan Bondeson, Fionula M. Brennan, +2

European Journal of Immunology

Adenoviral gene transfer of the endogenous inhibitor IkappaBalpha into human osteoarthritis synovial fibroblasts demonstrates that several matrix metalloproteinases and aggrecanases are nuclear factor-kappaB-dependent.

Jan Bondeson, Sarah N. Lauder, S.D. Wainwright, +5

PubMed

Everard Home, John Hunter, and Cutaneous Horns

Jan Bondeson

American Journal of Dermatopathology

Gross AnatomyCutaneous HornFolklore TraditionAnatomyDermatology +6