Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Abstract

Key Points Endogenous intronic long terminal repeats promote the ectopic expression of truncated ERBB4 transcripts in 24% of ALK-negative ALCL. The expression of ERBB4-aberrant transcripts defines a new subclass of ALK-negative ALCL and may contribute to ALCL transformation.