A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

Francesca Moretti, Barbara Marinari, Nadia Lo Iacono, +12

Journal of Clinical Investigation

Developmental BiologyHuman Congenital SyndromesCell RegulationGenetic DisorderGenetics +10

Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Irene Scarfò, Elisa Pellegrino, Elisabetta Mereu, +22

Blood

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p

Valentina Audrito, Sara Serra, Aureliano Stingi, +14

Oncotarget

ImmunologyImmunoeditingPd-l1 Up-regulationImmunotherapyCancer Biology +14

Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22

Francesca Arruga, Branimir Gizdić, Cinzia Bologna, +19

Leukemia

Cell RegulationImmunologyTumor SuppressorAdult T-cell Leukemia-lymphomaMedicine +3

The Dlx5 and Foxg1 transcription factors, linked via miRNA-9 and -200, are required for the development of the olfactory and GnRH system

Giulia Garaffo, Daniele Conte, Paolo Provero, +11

Molecular and Cellular Neuroscience

IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies

Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, +16

Blood

BMP-Mediated Functional Cooperation between Dlx5;Dlx6 and Msx1;Msx2 during Mammalian Limb Development

Maxence Vieux-Rochas, Kamal Bouhali, Stefano Mantero, +11

PLoS ONE

GeneticsLimb DevelopmentTranscriptional RegulationMsx MutantsBmp-mediated Functional Cooperation +14

DLX5, FGF8 and the Pin1 isomerase control ΔNp63α protein stability during limb development: a regulatory loop at the basis of the SHFM and EEC congenital malformations

Michela Restelli, Teresa Lopardo, Nadia Lo Iacono, +9

Human Molecular Genetics

Regulatory LoopGeneticsLimb DevelopmentEmbryologyTranscriptional Regulation +24

The apical ectodermal ridge of the mouse model of ectrodactyly<i>Dlx5;Dlx6</i>^−/−shows altered stratification and cell polarity, which are restored by exogenous Wnt5a ligand

Daniele Conte, Giulia Garaffo, Nadia Lo Iacono, +7

Human Molecular Genetics

Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome

Giulia Garaffo, Paolo Provero, Ivan Molineris, +8

Frontiers in Endocrinology