Irene Scarfò

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

Benjamin P. Kleinstiver, Alexander A. Sousa, Russell T. Walton et al. · Nature Biotechnology · 2019 · 690 citations

Base Editing, Engineered Crispr–cas12a Variants, Engineering +12

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

Bryan D. Choi, Xiaoling Yu, Ana P. Castaño et al. · Nature Biotechnology · 2019 · 539 citations

Immunological Memory, Autoimmune Disease, Immunology +9

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

Rebecca C. Larson, Michael C. Kann, Stefanie R. Bailey et al. · Nature · 2022 · 330 citations

Liquid Tumours, Cancer Immunosurveillance, Immunology +11

CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma

Bryan D. Choi, Xiaoling Yu, Ana P. Castaño et al. · Journal for ImmunoTherapy of Cancer · 2019 · 271 citations · Full text

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide

Max Jan, Irene Scarfò, Rebecca C. Larson et al. · Science Translational Medicine · 2021 · 243 citations · Full text