A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Shi Du Yan, Xi Chen, Jin Fu et al. · Nature · 1996 · 2K citations

Life Sciences, Neurobiology, Neuroscience +12

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Rashid Deane, Shi Du Yan, Ram Kumar Submamaryan et al. · Nature Medicine · 2003 · 1.4K citations

Life Sciences, Neurobiology, Neuroscience +14

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

Mahiuddin Ahmed, Judianne Davis, Darryl Aucoin et al. · Nature Structural & Molecular Biology · 2010 · 1.1K citations · Full text

Life Sciences, Biochemistry, Neuroscience +14

Curcumin labels amyloid pathology <i>in vivo</i> , disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model

Mónica Garcı́a-Alloza, Laura A. Borrelli, Anete Rozkalne et al. · Journal of Neurochemistry · 2007 · 652 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

Sadim Jawhar, Anna Trawicka, Carolin Jenneckens et al. · Neurobiology of Aging · 2010 · 613 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17