Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

Yan Li, Xin Chen, Ronghua Jin, +11

Science Advances

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination

Zhenzhen Zhan, Xuefeng Xie, Hao Cao, +4

Autophagy

MitophagyInflammatory Lung DiseaseTlr ActivationImmunologyImmune Regulation +27

Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination

Xingguang Liu, Hao Cao, Jian Li, +5

Cell Death and Differentiation

Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1

Binbin Cheng, Yichang Ren, Hao Cao, +1

European Journal of Medicinal Chemistry

Medicinal ChemistryEngineeringDual InhibitorsMedicineDrug Discovery +6

The insert sequence in SARS-CoV-2 enhances spike protein cleavage by TMPRSS

Tong Meng, Hao Cao, Hao Zhang, +14

Virus StructureProtease RecognitionSignal TransductionSars-cov-2 EnhancesSpike Protein +12

Factors influencing the adoption of mobile service in China: An integration of TAM

Quan Sun, Hao Cao, Jianxin You

Journal of Computers

Customer SatisfactionConsumer UncertaintyInnovation AdoptionDigital MarketingConsumer Research +17

Ferulic Acid Inhibits the Transition of Amyloid-β42 Monomers to Oligomers but Accelerates the Transition from Oligomers to Fibrils

Lili Cui, Yuan Zhang, Hao Cao, +6

Journal of Alzheimer s Disease

A Novel, Multi-Target Natural Drug Candidate, Matrine, Improves Cognitive Deficits in Alzheimer’s Disease Transgenic Mice by Inhibiting Aβ Aggregation and Blocking the RAGE/Aβ Axis

Lili Cui, Yujie Cai, Wanwen Cheng, +12

Molecular Neurobiology

Rage/aβ AxisNeurodegenerative DiseasesAlzheimer's DiseaseAβ AggregationMedicine +9

The transmembrane serine protease inhibitors are potential antiviral drugs for 2019-nCoV targeting the insertion sequence-induced viral infectivity enhancement

Tong Meng, Hao Cao, Hao Zhang, +14

Viral PathogenesisMolecular BiologyPotential Antiviral DrugsAntiviral DrugViral Structural Protein +14

Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment

Binbin Cheng, Wei Wang, Xiaoge Niu, +9

Journal of Medicinal Chemistry