Concepedia

Filtering promiscuous compounds in early drug discovery: is it a good idea?

Mário Roberto Senger, Carlos Alberto Manssour Fraga, Rafael Ferreira Dantas, Floriano Paes Silva

Drug Discovery Today · 2016 · 92 citations · 14 references

DOI

Concepts

References

14

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

Jonathan B. Baell, Georgina A. Holloway · Journal of Medicinal Chemistry · 2010 · 3.9K citations

, , +14

Chemistry: Chemical con artists foil drug discovery

Jonathan B. Baell, Michael A. Walters · Nature · 2014 · 1.1K citations · Full text

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The Chemical Space Project

Jean‐Louis Reymond · Accounts of Chemical Research · 2015 · 702 citations · Full text

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A detergent-based assay for the detection of promiscuous inhibitors

Brian Y. Feng, Brian K. Shoichet · Nature Protocols · 2006 · 436 citations · Full text

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High-throughput assays for promiscuous inhibitors

Brian Y. Feng, Anang A. Shelat, Thompson N. Doman et al. · Nature Chemical Biology · 2005 · 337 citations

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