Human CYP2C9 and CYP2A6 Mediate Formation of the Hepatotoxin 4-Ene-Valproic Acid

Valproic acid hepatic fatalities

Fritz E. Dreifuss, Nancy Santilli, D Langer et al. · Neurology · 1987 · 487 citations

Pharmacy, Pharmacology, Pharmacotherapy +14

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

Lydiane Pichard, Isabelle Fabre, Gérard Fabre et al. · Drug Metabolism and Disposition · 1990 · 437 citations

Medicine, Pharmacology, Toxicology +17

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

Shigeru Yamano, Jun Tatsuno, Frank J. Gonzalez · Biochemistry · 1990 · 384 citations

Medicine, Biochemistry, Pharmacology +8

Valproic acid hepatic fatalities. III. U.S. experience since 1986

Alton E. Bryant, Fritz E. Dreifuss · Neurology · 1996 · 340 citations

Pharmacy, Pediatric Pharmacy, Pharmacotherapy +13

Identification of an inducible form of cytochrome P-450 in human liver.

Paul B. Watkins, Steven Wrighton, Patrick Maurel et al. · Proceedings of the National Academy of Sciences · 1985 · 323 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +15