Concepedia

A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor

Junichi Endo, Hidemasa Hikawa, Maiko Hamada, Seigo Ishibuchi, Naoto Fujie, Naoki Sugiyama, Minoru Tanaka, Haruhito Kobayashi, Kunio Sugahara, Koichi Oshita,

Bioorganic & Medicinal Chemistry Letters · 2016 · 12 citations · 7 references

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7

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.3K citations · Full text

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

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The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

Anup Dey, Farideh Chitsaz, Asim Abbasi et al. · Proceedings of the National Academy of Sciences · 2003 · 671 citations · Full text

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Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite.

Tetsuro Fujita, Ken‐ichiro Inoue, Satoshi Yamamoto et al. · The Journal of Antibiotics · 1994 · 543 citations · Full text

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Growth and Early Postimplantation Defects in Mice Deficient for the Bromodomain-Containing Protein Brd4

Denis Houzelstein, Simon L. Bullock, Denise Lynch et al. · Molecular and Cellular Biology · 2002 · 315 citations · Full text

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