Evaluation of Effectiveness of Honey-Based Alginate Hyrogel on Wound Healing in a Mouse Model of Rat

Abstract

Alginate hydrogel and honey have a notably effect on wound healing process, therefore assessment of combined impact of those are essential. In this study, the effect of homey-based alginate hydrogel, alginate hydrogel and commercial alginate dressings in recovery of wound in a mouse model was studied. In this study, 20 Wistar rats were divided into four groups of five. One wound with dimension 1×1 cm square was created on either side of the vertebral column between the ears. One of the rats in each group were euthanized at 4, 7, 14, and 21 days and skin samples were taken for histopathological analysis. Findings showed that the average total time of wound healing in group of treated with honey-based alginate hydrogel dressing was the best treatment.With respect to all information obtained of the study we found that the honey-based alginate hydrogelis much convenient for wound dressing and treatment of surface wounds. Therefore, Outcomes of the treatment make our dressing highly promising as an alternative wound healing system for the treatment of wounds and certainly opening new path for future research and development.