A novel triazole derivative of betulinic acid induces extrinsic and intrinsic apoptosis in human leukemia HL-60 cells

Bax and Bak Coalesce into Novel Mitochondria-Associated Clusters during Apoptosis

Amotz Nechushtan, Carolyn L. Smith, Itschak Lamensdorf et al. · The Journal of Cell Biology · 2001 · 476 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

Simone Fulda, Claudia Friesen, Carsten Scaffidi et al. · PubMed · 1997 · 348 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Copper-catalyzed synthesis of aryl azides and 1-aryl-1,2,3-triazoles from boronic acids

Chuan‐Zhou Tao, Xin Cui, Juan Li et al. · Tetrahedron Letters · 2007 · 213 citations

Natural Sciences, Chemistry, Medicinal Chemistry +15

Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types

Jan H. Kessler, Franziska B. Mullauer, Guido M. de Roo et al. · Cancer Letters · 2006 · 187 citations

Medicine, Cancer Biology, Oncology +9

Effects of Betulinic Acid Alone and in Combination with Irradiation in Human Melanoma Cells

Edgar Selzer, Emilio Pimentel, Volker Wacheck et al. · Journal of Investigative Dermatology · 2000 · 175 citations · Full text

Medicine, Cancer Biology, Oncology +8