Concepedia

Identification of an orally available compound with potent and broad FLT3 inhibition activity

Ye Chen, Yingjie Guo, Wanke Zhao, W-T Tina Ho, Xueqi Fu, Zhizhuang Joe Zhao

Oncogene · 2015 · 27 citations · 32 references

DOI

Concepts

References

32

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith, Qi Wang, Chen-Shan Chin et al. · Nature · 2012 · 745 citations

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Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412

Richard M. Stone, Daniel J. DeAngelo, Virginia M. Klimek et al. · Blood · 2004 · 660 citations · Full text

, , +14

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 644 citations · Full text

, , +14

Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412

Ellen Weisberg, Christina Boulton, Louise Kelly et al. · Cancer Cell · 2002 · 602 citations · Full text

, , +14

Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors

Katrin Mackarehtschian, Jeff Hardin, Katrd A. Moore et al. · Immunity · 1995 · 578 citations · Full text

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