Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Dominique Bonnet, John E. Dick · Nature Medicine · 1997 · 6.9K citations

Medicine, Hematology, Oncology +14

Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.

Mitsushige Nakao, S Yokota, Toshiki Iwai et al. · PubMed · 1996 · 1.2K citations

Life Sciences, Genetics, Molecular Genetics +14

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

Yukiya Yamamoto · Blood · 2001 · 1.1K citations

Medicine, Genetics, Hematology +12

Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia.

Hitoshi Kiyoi, Tomoki Naoe, Yasuyuki Nakano et al. · PubMed · 1999 · 765 citations

Medicine, Genetics, Oncology +16

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

G Q Daley, David Baltimore · Proceedings of the National Academy of Sciences · 1988 · 593 citations · Full text

Medicine, Molecular Biology, Oncology +10