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Syntheses of Platinum–Sulindac Complexes and Their Nanoparticles as Targeted Anticancer Drugs

DOI

11

Citations

12

References

2016

Year

Jih Ru Hwu, Shwu‐Chen Tsay, Kao Shu Chuang, Mohit Kapoor, Jia Yu Lin, Chen‐Sheng Yeh, Wu‐Chou Su, Ping‐Ching Wu, Tsung‐Lin Tsai, Pei‐Wen Wang,
Chemistry - A European Journal

Abstract

Platinum(II)-sulindac complexes [{η<sup>2</sup> -C<sub>5</sub> H<sub>4</sub> SN(O)}Pt(DMSO){O(C=O)Sulindac}], [{η<sup>2</sup> -C<sub>5</sub> H<sub>4</sub> SN(O)}PtCl{(S=O)Sulindac}], [{η<sup>2</sup> -C<sub>5</sub> H<sub>4</sub> SN(O)}PtCl{(S=O)Sulindac-succinimide}], and [{η<sup>2</sup> -C<sub>5</sub> H<sub>4</sub> SN(O)}PtCl{(S=O)Sulindac-thymidine}] were synthesized that exhibited IC<sub>50</sub> values of 2.9-4.8 μm against human oral cancer cells OECM1. The poly(lactic-co-glycolic acid) (PLGA) encapsulated [{η<sup>2</sup> -C<sub>5</sub> H<sub>4</sub> SN(O)}PtCl{(S=O)Sulindac}] also showed cytotoxic activity although less potent than the pristine species.

References

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