Concepedia

Author

Sadao Hikishima

Tokyo University of Pharmacy and Life Sciences

Also Known As

S. Hikishima, Sadao Hikishima

33

Publications

561

Citations

11

H-Index

31

Concepts

All Affiliations

Tokyo University of Pharmacy and Life SciencesHokkaido UniversityUniversity of WarsawThe University of TokyoFukuoka University
SH

About

Sadao Hikishima is an author at Tokyo University of Pharmacy and Life Sciences specializing in medicine, natural sciences, and pharmacology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

7

7

257

2

Natural Sciences

6

6

189

3

Biochemistry

6

6

189

4

Engineering

2

2

103

5

Biomolecular Engineering

2

2

103

Sadao Hikishima

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12

Publications

500

Citations

11

H-Index

YearCitations

Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced colitis in mice

Akira Sakata, Takashi Ochiai, Hiroshi Shimeno,

Immunology

2007

107

New Base Pairing Motifs. The Synthesis and Thermal Stability of Oligodeoxynucleotides Containing Imidazopyridopyrimidine Nucleosides with the Ability to Form Four Hydrogen Bonds

Noriaki Minakawa, Naoshi Kojima, Sadao Hikishima,

Journal of the American Chemical Society

2003

107

Synthesis of 1,8‐Naphthyridine C‐Nucleosides and Their Base‐Pairing Properties in Oligodeoxynucleotides: Thermally Stable Naphthyridine:Imidazopyridopyrimidine Base‐Pairing Motifs

Sadao Hikishima, Noriaki Minakawa, Kazuyuki Kuramoto,

Angewandte Chemie International Edition

2004

80

Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice

Akira Sakata, Kazuya Yasuda, Takashi Ochiai,

Cellular Immunology

2007

43

Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs

Sadao Hikishima, Mariko Hashimoto, Lucyna Magnowska,

Bioorganic & Medicinal Chemistry

2010

35

Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP

Sadao Hikishima, Mariko Hashimoto, Lucyna Magnowska,

Bioorganic & Medicinal Chemistry Letters

2007

25

Synthesis of 1,8‐Naphthyridine C‐Nucleosides and Their Base‐Pairing Properties in Oligodeoxynucleotides: Thermally Stable Naphthyridine:Imidazopyridopyrimidine Base‐Pairing Motifs

Sadao Hikishima, Noriaki Minakawa, Kazuyuki Kuramoto,

Angewandte Chemie

2004

23

Synthesis and Characterization of Oligodeoxynucleotides Containing Naphthyridine:Imidazopyridopyrimidine Base Pairs at their Sticky Ends. Application as Thermally Stabilized Decoy Molecules

Sadao Hikishima, Noriaki Minakawa, Kazuyuki Kuramoto,

ChemBioChem

2006

21

Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors

Sadao Hikishima, Machiko Isobe, Satoru Koyanagi,

Bioorganic & Medicinal Chemistry

2005

21

Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state

Beata Wielgus‐Kutrowska, Katarzyna Breer, Mariko Hashimoto,

Bioorganic & Medicinal Chemistry

2012

15

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