Sadao Hikishima

Acid sphingomyelinase inhibition suppresses lipopolysaccharide‐mediated release of inflammatory cytokines from macrophages and protects against disease pathology in dextran sulphate sodium‐induced colitis in mice

Akira Sakata, Takashi Ochiai, Hiroshi Shimeno et al. · Immunology · 2007 · 107 citations · Full text

Chronic Inflammatory Diseases, Immunology, Pathology +17

New Base Pairing Motifs. The Synthesis and Thermal Stability of Oligodeoxynucleotides Containing Imidazopyridopyrimidine Nucleosides with the Ability to Form Four Hydrogen Bonds

Noriaki Minakawa, Naoshi Kojima, Sadao Hikishima et al. · Journal of the American Chemical Society · 2003 · 107 citations

Synthesis of 1,8‐Naphthyridine C‐Nucleosides and Their Base‐Pairing Properties in Oligodeoxynucleotides: Thermally Stable Naphthyridine:Imidazopyridopyrimidine Base‐Pairing Motifs

Sadao Hikishima, Noriaki Minakawa, Kazuyuki Kuramoto et al. · Angewandte Chemie International Edition · 2004 · 80 citations · Full text

Stable Naphthyridine, Bioorganic Chemistry, Engineering +16

Inhibition of lipopolysaccharide-induced release of interleukin-8 from intestinal epithelial cells by SMA, a novel inhibitor of sphingomyelinase and its therapeutic effect on dextran sulphate sodium-induced colitis in mice

Akira Sakata, Kazuya Yasuda, Takashi Ochiai et al. · Cellular Immunology · 2007 · 43 citations

Inflammation, Anti-inflammatory, Therapeutic Effect +9

Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs

Sadao Hikishima, Mariko Hashimoto, Lucyna Magnowska et al. · Bioorganic & Medicinal Chemistry · 2010 · 35 citations · Full text

Combinatorial Chemistry, Phosphate Mimic, Medicinal Chemistry +13