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Structural-based design and synthesis of novel 9-deazaguanine derivatives having a phosphate mimic as multi-substrate analogue inhibitors for mammalian PNPs

Combinatorial ChemistryPhosphate MimicMedicinal ChemistryBioorganic ChemistryBiochemistryNatural SciencesMedicineRational Drug DesignNovel 9-DeazaguaninePharmacotherapyDrug DevelopmentChemical BiologyPharmacologyPharmaceutical ChemistryMammalian PnpsDrug Discovery