Rapamycin-induced oligomer formation system of FRB–FKBP fusion proteins

A receptor for the immuno-suppressant FK506 is a cis–trans peptidyl-prolyl isomerase

Matthew W. Harding, David Uehling, Stuart L. Schreiber · Nature · 1989 · 1.4K citations

Molecular Immunology, Signal Transduction, Protein Expression +7

Characterization of the FKBP·Rapamycin·FRB Ternary Complex

Laura A. Banaszynski, Corey W. Liu, Thomas J. Wandless · Journal of the American Chemical Society · 2005 · 616 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Jie Chen, Xiao-Feng Zheng, Eric J. Brown et al. · Proceedings of the National Academy of Sciences · 1995 · 565 citations · Full text

A causative link between the structure of aberrant protein oligomers and their toxicity

Silvia Campioni, Benedetta Mannini, Mariagioia Zampagni et al. · Nature Chemical Biology · 2010 · 546 citations · Full text

Aberrant Protein Oligomers, Causative Link, Protein Function +10

A humanized system for pharmacologic control of gene expression

Victor M. Rivera, Tim Clackson, Sridaran Natesan et al. · Nature Medicine · 1996 · 541 citations

Systems Biology, Medicine, Pharmacogenomics +4