Concepedia

Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): a pathogenetic role of the tumor supressor genes PTEN/MMAC1 and MXI1?

Reiner Siebert, Stefan Gesk, Svetlana Harder, Sebastian Plötz, Peter Matthiesen, W. Grote, Brigitte Schlegelberger, Burkhard Jandrig, Unn-Hilde Grasmo-Wendler, Siegfried Scherneck,

PubMed · 1998 · 26 citations · 14 references

DOI

Abstract

To the Editor: The translocation t(14;18)(q32;q21), characteristic for follicular lymphomas and a subset of diffuse large cell lymphomas, juxtaposes the bcl-2 proto-oncogene with the Ig heavy-chain (IgH) gene. This results in deregulation of the bcl-2 gene expression and elevation of BCL-2 protein

References

14

<i>PTEN</i> , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li, Clifford Yen, Danny Liaw et al. · Science · 1997 · 4.8K citations

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser et al. · Nature Genetics · 1997 · 2.8K citations

, , +10

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta.

Dongmei Li, Hong Sun · PubMed · 1997 · 875 citations

, , +16

Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.

Per Guldberg, Per thor Straten, Anette Birck et al. · PubMed · 1997 · 486 citations

, , +17

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.

Dahong Teng, Rong Hu, Huai Lin et al. · PubMed · 1997 · 471 citations

, , +17