Concepedia

Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging

Shona H. Wood, Sipko van Dam, Thomas Craig, Robi Tăcutu, Amy O’Toole, Brian J. Merry, João Pedro de Magalhães

Genome biology · 2015 · 73 citations · 65 references

DOIFull text

Open access

Abstract

This study presents extensive data on the effects of diet and aging on the cerebral cortex transcriptome, and also emphasises the importance of epigenetics and post-translational modifications in longevity and neuroprotection.

References

65

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Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 54.5K citations · Full text

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Da Wei Huang, Brad T. Sherman, Richard A. Lempicki · Nature Protocols · 2008 · 36.7K citations

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PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Vamsi K. Mootha, Cecilia M. Lindgren, Karl‐Fredrik Eriksson et al. · Nature Genetics · 2003 · 10.4K citations

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ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

Gabriela Bindea, Bernhard Mlecnik, Hubert Hackl et al. · Bioinformatics · 2009 · 6.5K citations · Full text