PLoS ONE · 2015 · 27 citations · 43 references
Cell GrowthTgf-β Receptor SegregationCellular PhysiologyMolecular PharmacologyTgf-β SignalingEndocytic PathwayFibroblast Growth FactorEuphorbia TirucalliCell SignalingMolecular SignalingMolecular PhysiologyOxysterolLipid RaftsMembrane BiologyLipid ScienceTgf-β ResponsivenessPharmacologyCell BiologySignal TransductionDevelopmental BiologyTgf-β Receptor MovementPhysiologyCellular BiochemistryMedicineLipid Synthesis
Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.
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SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor
Tomoo Tsukazaki, Theodore Chiang, Anne Frances Davison et al. · Cell · 1998 · 955 citations · Full text
Molecular Physiology, Signal Transduction, Signaling Pathway +9