Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Colin Selman, Jennifer M. A. Tullet, Daniela Wieser et al. · Science · 2009 · 1.1K citations

Anti-aging, Molecular Regulation, Cell Death +22

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

Hiroshi Shima · The EMBO Journal · 1998 · 631 citations · Full text

Knockout Mouse, Signal Transduction, Molecular Physiology +10

Dysregulation of mTOR Signaling in Fragile X Syndrome

Ali Sharma, Charles A. Hoeffer, Yukihiro Takayasu et al. · Journal of Neuroscience · 2010 · 554 citations · Full text

Chronic Pharmacological mGlu5 Inhibition Corrects Fragile X in Adult Mice

Aubin Michalon, Michael S. Sidorov, Theresa M. Ballard et al. · Neuron · 2012 · 480 citations · Full text

Knockout Mouse, Molecular Pharmacology, Molecular Neuroscience +8

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

Emily K. Osterweil, Dilja Krueger‐Burg, Kimberly Reinhold et al. · Journal of Neuroscience · 2010 · 378 citations · Full text

Fmr1 Ko Mice, Genetics, Mrna Translation +18